A multifunctional electronic suture for continuous strain monitoring and on-demand drug release
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이연택 | - |
dc.contributor.author | 김화중 | - |
dc.contributor.author | YeonJu Kim | - |
dc.contributor.author | 노승범 | - |
dc.contributor.author | CHUNBEOMSOO | - |
dc.contributor.author | 김진호 | - |
dc.contributor.author | CharnMin Park | - |
dc.contributor.author | 최민영 | - |
dc.contributor.author | KIJUNPARK | - |
dc.contributor.author | 이재홍 | - |
dc.contributor.author | JUNGMOK SEO | - |
dc.date.accessioned | 2021-11-30T10:40:48Z | - |
dc.date.available | 2021-11-30T10:40:48Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5253 | - |
dc.description.abstract | Surgical sutures are widely used for closing wounds in skin. However, the monitoring of wound integrity and promoting tissue regeneration at the same time still remains a challenge. To address this, we developed a drug-releasing electronic suture system (DRESS) to monitor the suture integrity in real-time and enhance tissue regeneration by triggered drug release. DRESS was fabricated by using a single fiber with a core?shell structure consisting of a stretchable conductive fiber core and a thermoresponsive polymer shell containing drugs. The highly conductive fiber core acts as a strain sensor that enables continuous monitoring of suture strain with high sensitivity (a gauge factor of ∼686) and mechanical durability (being able to endure more than 3000 stretching cycles). The thermoresponsive shell layer composed of flexible poly(vinyl alcohol) (PVA) grafted onto poly(N-isopropylacrylamide) (PNIPAm) facilitates on-demand drug release via Joule heating. The results of an in vitro scratch assay showed a 66% decrease in wound area upon heat-activation after 48 hours demonstrating the stimuli-responsive therapeutic efficacy of DRESS by promoting cell migration. Moreover, ex vivo testing on porcine skin demonstrated the applicability of DRESS as a electronic suture. The approach used for DRESS provides insight into multifunctional sutures and offers additional therapeutic and diagnostic options for clinical applications. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | A multifunctional electronic suture for continuous strain monitoring and on-demand drug release | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1039/d1nr04508c | - |
dc.identifier.scopusid | 2-s2.0-85119365400 | - |
dc.identifier.bibliographicCitation | NANOSCALE, v.13, no.43, pp 18112 - 18124 | - |
dc.citation.title | NANOSCALE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 43 | - |
dc.citation.startPage | 18112 | - |
dc.citation.endPage | 18124 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Smart suture | - |
dc.subject.keywordAuthor | Bioelectronics | - |
dc.subject.keywordAuthor | Strain sensor | - |
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