Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Soojeong Choi | - |
dc.contributor.author | Jong Seung Lee | - |
dc.contributor.author | Jisoo Shin | - |
dc.contributor.author | Min Suk Lee | - |
dc.contributor.author | Donyoung Kang | - |
dc.contributor.author | Nathaniel S. Hwang | - |
dc.contributor.author | Hyungsuk Lee | - |
dc.contributor.author | Hee Seok Yang | - |
dc.contributor.author | Seung-Woo Cho | - |
dc.date.accessioned | 2021-11-30T10:40:50Z | - |
dc.date.available | 2021-11-30T10:40:50Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5260 | - |
dc.description.abstract | Bio-inspired adhesive hydrogels have been applied to cell and drug delivery systems to address various tissue defects and disorders. However, adhesive hydrogels functionalized with phenolic moieties often lack osteoconductive capacity and mechanical properties for bone regeneration. In this study, we utilized the versatile chemical interactions of phenolic moieties to overcome such limitations in bone tissue engineering efforts. Highly osteoconductive hybrid hydrogel patches were fabricated by incorporating inorganic minerals, hydroxyapatite (HAP), or whitlockite (WKT), into pyrogallol-conjugated hyaluronic acid (HA-PG). The hybrid HA-PG patches exhibited improved mechanical strength and reinforced structural/physical properties owing to additional intermolecular complexation between oxidized PG moieties and ions released from inorganic particles. The sustained release of bone morphogenetic protein-2 (BMP-2) from hybrid patches was prolonged by combination of the inherent nucleophilic affinity of oxidized PG and electrostatic interactions between inorganic particles and BMP-2. With increased osteoconductivity, hybrid patches with HAP or WKT enhanced the osteogenic differentiation of human stem cells while also promoting new bone formation in a critical-sized calvarial defect. Our study demonstrates a translational potential of phenolic adhesive hydrogels engineered with inorganic minerals for orthopedic applications. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jconrel.2020.09.006 | - |
dc.identifier.scopusid | 2-s2.0-85090571688 | - |
dc.identifier.wosid | 000585933700041 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.327, pp 571 - 583 | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 327 | - |
dc.citation.startPage | 571 | - |
dc.citation.endPage | 583 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | Adhesives | - |
dc.subject.keywordPlus | Biogeochemistry | - |
dc.subject.keywordPlus | Biomechanics | - |
dc.subject.keywordPlus | Biomimetics | - |
dc.subject.keywordPlus | Bone | - |
dc.subject.keywordPlus | Controlled drug delivery | - |
dc.subject.keywordPlus | Defects | - |
dc.subject.keywordPlus | Hydrogels | - |
dc.subject.keywordPlus | Hydroxyapatite | - |
dc.subject.keywordPlus | Organic acids | - |
dc.subject.keywordPlus | Stem cells | - |
dc.subject.keywordPlus | Targeted drug delivery | - |
dc.subject.keywordPlus | Tissue | - |
dc.subject.keywordPlus | Tissue regeneration | - |
dc.subject.keywordPlus | Bone morphogenetic protein-2 | - |
dc.subject.keywordPlus | Bone tissue engineering | - |
dc.subject.keywordPlus | Chemical interactions | - |
dc.subject.keywordPlus | Hyaluronic acid hydrogels | - |
dc.subject.keywordPlus | Hydroxyapatite (HAp) | - |
dc.subject.keywordPlus | Intermolecular complexation | - |
dc.subject.keywordPlus | Orthopedic applications | - |
dc.subject.keywordPlus | Osteogenic differentiation | - |
dc.subject.keywordPlus | Hyaluronic acid | - |
dc.subject.keywordPlus | bone morphogenetic protein 2 | - |
dc.subject.keywordPlus | calcium phosphate | - |
dc.subject.keywordPlus | hyaluronic acid | - |
dc.subject.keywordPlus | hydrogel | - |
dc.subject.keywordPlus | hydroxyapatite | - |
dc.subject.keywordPlus | adipose derived stem cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | bone conduction | - |
dc.subject.keywordPlus | bone regeneration | - |
dc.subject.keywordPlus | bone tissue | - |
dc.subject.keywordPlus | cell differentiation | - |
dc.subject.keywordPlus | chemical interaction | - |
dc.subject.keywordPlus | compressive strength | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug delivery system | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nanofabrication | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | nucleophilicity | - |
dc.subject.keywordPlus | ossification | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | proton nuclear magnetic resonance | - |
dc.subject.keywordPlus | scanning electron microscopy | - |
dc.subject.keywordPlus | static electricity | - |
dc.subject.keywordPlus | surface charge | - |
dc.subject.keywordPlus | sustained drug release | - |
dc.subject.keywordPlus | tissue engineering | - |
dc.subject.keywordPlus | Young modulus | - |
dc.subject.keywordAuthor | Bone regeneration | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Hydroxyapatite | - |
dc.subject.keywordAuthor | Osteoconductive hydrogel patch | - |
dc.subject.keywordAuthor | Pyrogallol | - |
dc.subject.keywordAuthor | Whitlockite | - |
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