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Cell-Membrane-Derived Nanoparticles with Notch-1 Suppressor Delivery Promote Hypoxic Cell–Cell Packing and Inhibit Angiogenesis Acting as a Two-Edged Sword

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dc.contributor.authorHYESEON KIM-
dc.contributor.authorYOUNG MIN SHIN-
dc.contributor.authorSeyong Chung-
dc.contributor.authorDA HEE KIM-
dc.contributor.authorPark D.B.-
dc.contributor.authorSEWOOM BAEK-
dc.contributor.authorJEONGGEUN PARK-
dc.contributor.authorSIYEONG KIM-
dc.contributor.authorKim D.-H.-
dc.contributor.authorSE WON YI-
dc.contributor.authorSONGHYUN LEE-
dc.contributor.authorLee J.B.-
dc.contributor.authorKo J.-Y.-
dc.contributor.authorIm G.-I.-
dc.contributor.authorMI-LAN KANG-
dc.contributor.authorHak-Joon Sung-
dc.date.accessioned2021-12-01T02:40:10Z-
dc.date.available2021-12-01T02:40:10Z-
dc.date.created2021-10-21-
dc.date.issued2021-10-
dc.identifier.issn0935-9648-
dc.identifier.urihttps://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5269-
dc.description.abstractCell?cell interactions regulate intracellular signaling via reciprocal contacts of cell membranes in tissue regeneration and cancer growth, indicating a critical need of membrane-derived tools in studying these processes. Hence, cell-membrane-derived nanoparticles (CMNPs) are produced using tonsil-derived mesenchymal stem cells (TMSCs) from children owing to their short doubling time. As target cell types, laryngeal cancer cells are compared to?bone-marrow-derived MSCs (BMSCs) because of their cartilage damaging and chondrogenic characteristics, respectively. Treating spheroids of these cell types with CMNPs exacerbates?interspheroid?hypoxia with robust maintenance of the cell?cell interaction signature for 7 days. Both cell types prefer a hypoxic environment, as opposed to blood vessel formation that is absent in cartilage but is required for cancer growth. Hence, angiogenesis is inhibited by displaying the Notch-1 aptamer on CMNPs. Consequently, laryngeal cancer growth is suppressed efficiently in contrast to improved chondroprotection observed in a series of cell and animal experiments using a xenograft mouse model of laryngeal cancer.?Altogether, CMNPs execute?a two-edged sword function of?inducing hypoxic cell?cell packing, followed by suppressing angiogenesis to promote?laryngeal cancer death and chondrogenesis?simultaneously.?This study presents a previously unexplored therapeutic strategy for anti-cancer and chondroprotective treatment using CMNPs.-
dc.language영어-
dc.language.isoen-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleCell-Membrane-Derived Nanoparticles with Notch-1 Suppressor Delivery Promote Hypoxic Cell–Cell Packing and Inhibit Angiogenesis Acting as a Two-Edged Sword-
dc.typeArticle-
dc.contributor.affiliatedAuthorHYESEON KIM-
dc.contributor.affiliatedAuthorYOUNG MIN SHIN-
dc.contributor.affiliatedAuthorSeyong Chung-
dc.contributor.affiliatedAuthorDA HEE KIM-
dc.contributor.affiliatedAuthorSEWOOM BAEK-
dc.contributor.affiliatedAuthorJEONGGEUN PARK-
dc.contributor.affiliatedAuthorSIYEONG KIM-
dc.contributor.affiliatedAuthorSE WON YI-
dc.contributor.affiliatedAuthorSONGHYUN LEE-
dc.contributor.affiliatedAuthorMI-LAN KANG-
dc.contributor.affiliatedAuthorHak-Joon Sung-
dc.identifier.doi10.1002/adma.202101558-
dc.identifier.scopusid2-s2.0-85113329211-
dc.identifier.bibliographicCitationADVANCED MATERIALS, v.33, no.40, pp.2,101,558-
dc.relation.isPartOfADVANCED MATERIALS-
dc.citation.titleADVANCED MATERIALS-
dc.citation.volume33-
dc.citation.number40-
dc.citation.startPage2,101,558-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorcell membranes-
dc.subject.keywordAuthorcell?cell packing-
dc.subject.keywordAuthorhypoxia-
dc.subject.keywordAuthornanoparticles-
dc.subject.keywordAuthorNotch-1 aptamers-
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