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A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording

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dc.contributor.author이연택-
dc.contributor.author신효근-
dc.contributor.author이동원-
dc.contributor.author최성아-
dc.contributor.author조일주-
dc.contributor.authorJUNGMOK SEO-
dc.date.accessioned2021-12-01T02:40:12Z-
dc.date.available2021-12-01T02:40:12Z-
dc.date.issued2021-08-
dc.identifier.issn2198-3844-
dc.identifier.urihttps://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5275-
dc.description.abstractBrain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune-stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs.-
dc.language영어-
dc.language.isoENG-
dc.publisherWiley-vch Verlag GmbH &Co-
dc.titleA Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording-
dc.typeArticle-
dc.publisher.location네델란드-
dc.identifier.doi10.1002/advs.202100231-
dc.identifier.scopusid2-s2.0-85107116454-
dc.identifier.bibliographicCitationAdvanced Science, v.8, no.15, pp 2100231-1 - 2100231-14-
dc.citation.titleAdvanced Science-
dc.citation.volume8-
dc.citation.number15-
dc.citation.startPage2100231-1-
dc.citation.endPage2100231-14-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorNon-immunogenic-
dc.subject.keywordAuthorNeural probe-
dc.subject.keywordAuthorLongevity-
dc.subject.keywordAuthorSlippery-
dc.subject.keywordAuthorinsertion trauma minimization-
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