Multifunctional DNA Nanogels for Aptamer-Based Targeted Delivery and Stimuli-Triggered Release of Cancer Therapeutics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | KYUNGSENE LEE | - |
dc.contributor.author | KIM TAEHYUNG | - |
dc.contributor.author | YOUNG MIN KIM | - |
dc.contributor.author | KYUNGJIK YANG | - |
dc.contributor.author | 최인석 | - |
dc.contributor.author | Young Hoon Roh | - |
dc.date.accessioned | 2021-12-01T02:40:14Z | - |
dc.date.available | 2021-12-01T02:40:14Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1022-1336 | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5287 | - |
dc.description.abstract | Targeted, stimulus-responsive DNA nanogels hold considerable promise for cancer therapeutics. To expand their functionality including thermoresponsiveness, here, multifunctional DNA nanogels are developed for potential application toward cancer-targeted delivery and stimuli-responsive release of cancer therapeutics. Three types of functionalized DNA nanobuilding units are formed into DNA nanogels of ?200?nm via sequence-dependent self-assembly. The sequence-dependent assembly of nanobuilding units is precisely designed for controlled assembly and thermal disassembly at physiological temperatures. The supramolecular structure exhibits multifunctionalities including temperature-induced disassembly, aptamer-mediated cancer cell targeting, and light-triggered temperature increase. The nanogels support co-loading of cancer therapeutics including anti-sense oligonucleotides and doxorubicin along with stimuli-responsive release of loaded drugs through temperature-responsive structural disassembly and pH-responsive deintercalation. The nanogels exhibit efficient aptamer-mediated cancer-specific intracellular delivery and combinational anticancer effects upon light triggering. The developed DNA nanogels, thus, constitute potential noncationic nanovectors for targeted delivery of combinational cancer therapeutics. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Multifunctional DNA Nanogels for Aptamer-Based Targeted Delivery and Stimuli-Triggered Release of Cancer Therapeutics | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/marc.202000457 | - |
dc.identifier.scopusid | 2-s2.0-85096654775 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RAPID COMMUNICATIONS, v.42, no.2, pp 2000457-1 - 2000457-6 | - |
dc.citation.title | MACROMOLECULAR RAPID COMMUNICATIONS | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 2000457-1 | - |
dc.citation.endPage | 2000457-6 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | cancer therapeutics | - |
dc.subject.keywordAuthor | DNA nanogels | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | gold nanoparticles | - |
dc.subject.keywordAuthor | stimuli?triggered release | - |
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