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Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides

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dc.contributor.authorCHAEWON PARK-
dc.contributor.authorJONG-WOO LIM-
dc.contributor.authorGEUNSEON PARK-
dc.contributor.authorHyun-Ouk Kim-
dc.contributor.author권유리-
dc.contributor.authorSeong-Eun Kim-
dc.contributor.authorMinjoo Yeom-
dc.contributor.authorWoonsung Na-
dc.contributor.authorDaesub Song-
dc.contributor.authorEUNJUNG KIM-
dc.contributor.authorSEUNGJOO HAAM-
dc.contributor.authorSojeong Lee-
dc.date.accessioned2021-12-10T03:40:09Z-
dc.date.available2021-12-10T03:40:09Z-
dc.date.created2021-12-10-
dc.date.issued2021-12-
dc.identifier.issn2050-750X-
dc.identifier.urihttps://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6022-
dc.description.abstractSpecific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for understanding the viral infection cycle. Inspired by this process, virus detection has been achieved using nanomaterials with host-mimetic membranes, enabling interactions with amphiphilic hemagglutinin fusion peptides of viruses. Most research has been on designing functional nanoparticles with fusogenic capability for virus detection, and there has been little exploitation of the kinetic stability to alter the ability of nanoparticles to interact with viral membranes and improve their sensing performance. In this study, a homogeneous fluorescent assay using self-assembled polymeric nanoparticles (PNPs) with tunable responsiveness to external stimuli is developed for rapid and straightforward detection of an activated influenza A virus. Dissociation of PNPs induced by virus insertion can be readily controlled by varying the fraction of hydrophilic segments in copolymers constituting PNPs, giving rise to fluorescence signals within 30 min and detection of various influenza viruses, including H9N2, CA04(H1N1), H4N6, and H6N8. Therefore, the designs demonstrated in this study propose underlying approaches for utilizing engineered PNPs through modulation of their kinetic stability for direct and sensitive identification of infectious viruses.-
dc.language영어-
dc.language.isoen-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleKinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides-
dc.typeArticle-
dc.contributor.affiliatedAuthorCHAEWON PARK-
dc.contributor.affiliatedAuthorJONG-WOO LIM-
dc.contributor.affiliatedAuthorGEUNSEON PARK-
dc.contributor.affiliatedAuthor권유리-
dc.contributor.affiliatedAuthorEUNJUNG KIM-
dc.contributor.affiliatedAuthorSEUNGJOO HAAM-
dc.identifier.doi10.1039/D1TB01847G-
dc.identifier.scopusid2-s2.0-85121101603-
dc.identifier.bibliographicCitationJOURNAL OF MATERIALS CHEMISTRY B, v.9, no.47, pp.9,658 - 9,669-
dc.relation.isPartOfJOURNAL OF MATERIALS CHEMISTRY B-
dc.citation.titleJOURNAL OF MATERIALS CHEMISTRY B-
dc.citation.volume9-
dc.citation.number47-
dc.citation.startPage9,658-
dc.citation.endPage9,669-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.subject.keywordAuthormechanistic analysis-
dc.subject.keywordAuthorinfluenza virus detection-
dc.subject.keywordAuthorpolymeric nanoparticle-
dc.subject.keywordAuthorhost-cell-mimic system-
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