Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHAEWON PARK | - |
dc.contributor.author | JONG-WOO LIM | - |
dc.contributor.author | GEUNSEON PARK | - |
dc.contributor.author | Hyun-Ouk Kim | - |
dc.contributor.author | Sojeong Lee | - |
dc.contributor.author | 권유리 | - |
dc.contributor.author | Seong-Eun Kim | - |
dc.contributor.author | Minjoo Yeom | - |
dc.contributor.author | Woonsung Na | - |
dc.contributor.author | Daesub Song | - |
dc.contributor.author | EUNJUNG KIM | - |
dc.contributor.author | SEUNGJOO HAAM | - |
dc.date.accessioned | 2021-12-10T03:40:09Z | - |
dc.date.available | 2021-12-10T03:40:09Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6022 | - |
dc.description.abstract | Specific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for understanding the viral infection cycle. Inspired by this process, virus detection has been achieved using nanomaterials with host-mimetic membranes, enabling interactions with amphiphilic hemagglutinin fusion peptides of viruses. Most research has been on designing functional nanoparticles with fusogenic capability for virus detection, and there has been little exploitation of the kinetic stability to alter the ability of nanoparticles to interact with viral membranes and improve their sensing performance. In this study, a homogeneous fluorescent assay using self-assembled polymeric nanoparticles (PNPs) with tunable responsiveness to external stimuli is developed for rapid and straightforward detection of an activated influenza A virus. Dissociation of PNPs induced by virus insertion can be readily controlled by varying the fraction of hydrophilic segments in copolymers constituting PNPs, giving rise to fluorescence signals within 30 min and detection of various influenza viruses, including H9N2, CA04(H1N1), H4N6, and H6N8. Therefore, the designs demonstrated in this study propose underlying approaches for utilizing engineered PNPs through modulation of their kinetic stability for direct and sensitive identification of infectious viruses. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1039/D1TB01847G | - |
dc.identifier.scopusid | 2-s2.0-85121101603 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.9, no.47, pp 9,658 - 9,669 | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 9 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | 9,658 | - |
dc.citation.endPage | 9,669 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.subject.keywordAuthor | mechanistic analysis | - |
dc.subject.keywordAuthor | influenza virus detection | - |
dc.subject.keywordAuthor | polymeric nanoparticle | - |
dc.subject.keywordAuthor | host-cell-mimic system | - |
Items in Scholar Hub are protected by copyright, with all rights reserved, unless otherwise indicated.
Yonsei University 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea1599-1885
© 2021 YONSEI UNIV. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.