Cancer Patient Tissueoid with Self-Homing Nano-Targeting of Metabolic Inhibitor
DC Field | Value | Language |
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dc.contributor.author | HYO-JIN YOON | - |
dc.contributor.author | YOUNG SHIN CHUNG | - |
dc.contributor.author | Yong Jae Lee | - |
dc.contributor.author | Seung-Eun Yu | - |
dc.contributor.author | SEWOOM BAEK | - |
dc.contributor.author | HYESEON KIM | - |
dc.contributor.author | SANG WUN KIM | - |
dc.contributor.author | JUNG-YUN LEE | - |
dc.contributor.author | SUNG HOON KIM | - |
dc.contributor.author | Hak-Joon Sung | - |
dc.date.accessioned | 2022-01-12T09:40:08Z | - |
dc.date.available | 2022-01-12T09:40:08Z | - |
dc.date.created | 2022-01-12 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6278 | - |
dc.description.abstract | The current paradigm of cancer medicine focuses on patient- and/or cancer-specific treatments, which has led to continuous progress in the development of patient representatives (e.g., organoids) and cancer-targeting carriers for drug screening. As breakthrough concepts, i) living cancer tissues convey intact profiles of patient-specific microenvironmental signatures. ii) The growth mechanisms of cancer mass with intense cell-cell interactions can be harnessed to develop self-homing nano-targeting by using cancer cell-derived nanovesicles (CaNVs). Hence, a tissueoid model of ovarian cancer (OC) is developed by culturing OC patient tissues in a 3D gel chip, whose microchannel networks enable perfusion to maintain tissue viability. A novel model of systemic cancer responses is approached by xenografting OC tissueoids into ischaemic hindlimbs in nude mice. CaNVs are produced to carry general chemotherapeutics or new drugs under pre/clinical studies that target the BRCA mutation or energy metabolism, thereby increasing the test scope. This pioneer study cross-validates drug responses from the OC clinic, tissueoid, and animal model by demonstrating the alignment of results in drug type-specific efficiency, BRCA mutation-dependent drug efficiency, and metabolism inhibition-based anti-cancer effects. Hence, this study provides a directional foundation to accelerate the discovery of patient-specific drugs with CaNV application towards future precision medicine. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Wiley-vch Verlag GmbH &Co | - |
dc.title | Cancer Patient Tissueoid with Self-Homing Nano-Targeting of Metabolic Inhibitor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | HYO-JIN YOON | - |
dc.contributor.affiliatedAuthor | YOUNG SHIN CHUNG | - |
dc.contributor.affiliatedAuthor | Yong Jae Lee | - |
dc.contributor.affiliatedAuthor | Seung-Eun Yu | - |
dc.contributor.affiliatedAuthor | SEWOOM BAEK | - |
dc.contributor.affiliatedAuthor | HYESEON KIM | - |
dc.contributor.affiliatedAuthor | SANG WUN KIM | - |
dc.contributor.affiliatedAuthor | JUNG-YUN LEE | - |
dc.contributor.affiliatedAuthor | SUNG HOON KIM | - |
dc.contributor.affiliatedAuthor | Hak-Joon Sung | - |
dc.identifier.doi | 10.1002/advs.202105264 | - |
dc.identifier.scopusid | 2-s2.0-85117176783 | - |
dc.identifier.bibliographicCitation | Advanced Science, v.8, no.22, pp.1 - 13 | - |
dc.relation.isPartOf | Advanced Science | - |
dc.citation.title | Advanced Science | - |
dc.citation.volume | 8 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | cancer cell-derived nanovesicles | - |
dc.subject.keywordAuthor | ovarian cancer | - |
dc.subject.keywordAuthor | patient-specific treatments | - |
dc.subject.keywordAuthor | , self-homing nano-targeting | - |
dc.subject.keywordAuthor | tissueoid | - |
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