Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator
- Authors
- Seung-Eun Yu; Seyong Chung; HYUNSU HA; Dae-Hyun Kim; SEWOOM BAEK; TAEYOUNG KIM; SONGHYUN LEE; HYO-JIN YOON; Soon Won Chung; Jung Bok Lee; YOUNG MIN SHIN; HYESEON KIM; SIYEONG KIM; Joon-Sang Park; CHANGSOO KIM; Hak-Joon Sung
- Issue Date
- Apr-2022
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- CDK9; disturbed flow; nanotheranostics,; pre-stenotic vessel; targeting peptide
- Citation
- ADVANCED FUNCTIONAL MATERIALS, v.32, no.15, pp.2110368 - 2110368
- Journal Title
- ADVANCED FUNCTIONAL MATERIALS
- Volume
- 32
- Number
- 15
- Start Page
- 2110368
- End Page
- 2110368
- URI
- https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6293
- DOI
- 10.1002/adfm.202110368
- ISSN
- 1616-301X
- Abstract
- Navigation of nanoparticles to target sites of blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment of pre-stenotic vessels can prevent the irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using the navigation function and subsequent binding-on signaling of P. as a game-changer. When rabbit vessels are allografted with injecting contrast-loaded P. liposomes, the case-dependent stenotic degree after 2?6 weeks can be diagnosed accurately within 2?4 days via computed tomography imaging with cross-validation in a mouse model of partial carotid ligation. Furthermore, the anti-CDK9 signaling of P. NV is activated post-targeting and effectively prevents vascular stenosis by suppressing inflammation and lipotoxicity in the vessels, serum, and/or liver. CDK9 targeting is confirmed using computer, in vitro, and in vivo models. This study demonstrates an unprecedented nanotheranostic function for future clinical applications.
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- Appears in
Collections - College of Medicine > 의과대학 의학공학교실 > 1. Journal Articles

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