Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seung-Eun Yu | - |
dc.contributor.author | Seyong Chung | - |
dc.contributor.author | HYUNSU HA | - |
dc.contributor.author | Dae-Hyun Kim | - |
dc.contributor.author | SEWOOM BAEK | - |
dc.contributor.author | TAEYOUNG KIM | - |
dc.contributor.author | SONGHYUN LEE | - |
dc.contributor.author | HYO-JIN YOON | - |
dc.contributor.author | Soon Won Chung | - |
dc.contributor.author | Jung Bok Lee | - |
dc.contributor.author | YOUNG MIN SHIN | - |
dc.contributor.author | HYESEON KIM | - |
dc.contributor.author | SIYEONG KIM | - |
dc.contributor.author | Joon-Sang Park | - |
dc.contributor.author | CHANGSOO KIM | - |
dc.contributor.author | Hak-Joon Sung | - |
dc.date.accessioned | 2022-04-29T09:40:08Z | - |
dc.date.available | 2022-04-29T09:40:08Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6293 | - |
dc.description.abstract | Navigation of nanoparticles to target sites of blood flow disturbance markedly upgrades the diagnostic paradigm in vascular medicine. The theranostic treatment of pre-stenotic vessels can prevent the irreversible occlusion process effectively. Here, these nanotheranostic functions are established by displaying CDK9(cyclin-dependent kinase 9)-targeting peptide (P.) onto nanovesicles (NV) and liposomes using the navigation function and subsequent binding-on signaling of P. as a game-changer. When rabbit vessels are allografted with injecting contrast-loaded P. liposomes, the case-dependent stenotic degree after 2?6 weeks can be diagnosed accurately within 2?4 days via computed tomography imaging with cross-validation in a mouse model of partial carotid ligation. Furthermore, the anti-CDK9 signaling of P. NV is activated post-targeting and effectively prevents vascular stenosis by suppressing inflammation and lipotoxicity in the vessels, serum, and/or liver. CDK9 targeting is confirmed using computer, in vitro, and in vivo models. This study demonstrates an unprecedented nanotheranostic function for future clinical applications. | - |
dc.format.extent | 1 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Nanotheranostics of Pre-Stenotic Vessels By Target Touch-On Signaling of Peptide Navigator | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/adfm.202110368 | - |
dc.identifier.scopusid | 2-s2.0-85120793028 | - |
dc.identifier.wosid | 000728141300001 | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, v.32, no.15, pp 2110368 - 2110368 | - |
dc.citation.title | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 2110368 | - |
dc.citation.endPage | 2110368 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | CDK9 | - |
dc.subject.keywordAuthor | disturbed flow | - |
dc.subject.keywordAuthor | nanotheranostics, | - |
dc.subject.keywordAuthor | pre-stenotic vessel | - |
dc.subject.keywordAuthor | targeting peptide | - |
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