Scalp Micro-Pigmentation via Transcutaneous Implantation of Flexible Tissue Interlocking Biodegradable Microneedles
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lahiji, Shayan Fakhraei | - |
dc.contributor.author | Um, Daniel Junmin | - |
dc.contributor.author | Kim, Youseong | - |
dc.contributor.author | Jang, Jeesu | - |
dc.contributor.author | Yang, Huisuk | - |
dc.contributor.author | Jung, Hyungil | - |
dc.date.accessioned | 2023-04-21T01:40:19Z | - |
dc.date.available | 2023-04-21T01:40:19Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6618 | - |
dc.description.abstract | Alopecia, characterized by hair follicle blockage and hair loss, disrupts the normal cycle of hair growth. Although not a life-threatening condition, a growing body of evidence suggests that the psychological state of individuals experiencing alopecia can be highly influenced. Despite considerable research on hair loss treatment, interest in micro-pigmentation has increased in recent decades. Micro-pigmentation is an effective method to camouflage the visual contrast between the scalp and hair strands. However, the localization, intensity and dimension of microdots depend highly upon the physician performing the implantation. Incorrectly localized microdots within the skin may lead to patchy or faded micro-pigmentation. To overcome the limitations of conventional micro-pigmentation, we aimed to develop micro-pigment-encapsulated biodegradable microneedles (PBMs), capable of accurately implanting pigments below the epithelial-dermal junction of the scalp in a minimally invasive manner. A tissue interlocking microneedle technique was utilized to fabricate double-layered PBMs over a biodegradable flexible sheet, which could be washed off post-implantation. We confirmed that the intensity, dimension and insertion depth of 1000 mu m-long PBMs was maintained on pig cadaver skin over time. This study suggested that the developed PBMs would serve as an attractive platform for scalp micro-pigmentation in the future. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Scalp Micro-Pigmentation via Transcutaneous Implantation of Flexible Tissue Interlocking Biodegradable Microneedles | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/pharmaceutics11110549 | - |
dc.identifier.scopusid | 2-s2.0-85074331262 | - |
dc.identifier.wosid | 000502280100001 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICS, v.11, no.11 | - |
dc.citation.title | PHARMACEUTICS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 11 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | HAIR LOSS | - |
dc.subject.keywordPlus | TELOGEN-EFFLUVIUM | - |
dc.subject.keywordPlus | BALDNESS | - |
dc.subject.keywordPlus | ALOPECIA | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordAuthor | micro-pigmentation | - |
dc.subject.keywordAuthor | scalp camouflage | - |
dc.subject.keywordAuthor | flexible microneedle array | - |
dc.subject.keywordAuthor | transdermal implantation | - |
dc.subject.keywordAuthor | tissue interlocking microneedle | - |
Items in Scholar Hub are protected by copyright, with all rights reserved, unless otherwise indicated.
Yonsei University 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea1599-1885
© 2021 YONSEI UNIV. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.