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Catalyst-Free Construction of Imidazole-Pyrrolo[1,2-a]pyrazine Hybrid, 2,6-Disubstituted Imidazo[1,2-a]pyrrolo[2,1-c]pyrazine via Regioselective Annulative Functionalizations
- Oh, Hyunjin;
- 구도희;
- Jung, Myungho;
- Lee, Sunhee;
- Kim, Ikyon
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0초록
Highly efficient catalyst-free annulative functionalization approaches to a novel imidazole-pyrrolo[1,2-a]pyrazine hybrid structure were devised from the reaction of beta-enaminone with propargylamine where regioselective conjugate substitution of beta-enaminone with propargylamine followed by cycloisomerization proceeded smoothly in a domino fashion to construct two heterocyclic moieties (pyrazine and imidazole) via successive formation of three C-N bonds, leading to the target tricyclic skeleton.
- 제목
- Catalyst-Free Construction of Imidazole-Pyrrolo[1,2-a]pyrazine Hybrid, 2,6-Disubstituted Imidazo[1,2-a]pyrrolo[2,1-c]pyrazine via Regioselective Annulative Functionalizations
- 저자
- Oh, Hyunjin; 구도희; Jung, Myungho; Lee, Sunhee; Kim, Ikyon
- 발행일
- 2024-12
- 권
- 89
- 호
- 24
- 페이지
- 17966 ~ 17990