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Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
- KIM TAEHYUNG;
- HANA HYUN;
- Roun Heo;
- KEONWOOKNAM;
- KYUNGJIK YANG;
- 외 6명
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13Citations
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24초록
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
키워드
RNA nanotechnology; rolling circle transcription; siRNA; dual-targeting; cancer therapy; PROGRESS REPORT; IN-VITRO; MICROSPONGES; INTERFERENCE; NANOCARRIERS; CHALLENGES; DISEASE
- 제목
- Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
- 저자
- KIM TAEHYUNG; HANA HYUN; Roun Heo; KEONWOOKNAM; KYUNGJIK YANG; YOUNG MIN KIM; Yoon Suk Lee; Jae Yoon An; Jae Hyung Park; Ki Young Choi; Young Hoon Roh
- 발행일
- 2020-06
- 권
- 56
- 호
- 49
- 페이지
- 6,624 ~ 6,627
- 언어
- ENG
- 출판사
- ROYAL SOC CHEMISTRY
- 발행국가
- 영국
- ISSN
- P 1359-7345