ScholarWorks@Y-Scholar Hub

초록

Microplastics, ubiquitous in the human body, often undergo an aging process due to long-term exposure to indoor and outdoor environmental conditions. While recent attention has focused on the impact of microplastics on cancer proliferation and metastasis in mouse cancer models, the specific properties of microplastics that influence cancer growth remain poorly understood. In this study, we compared and analyzed cancer cell proliferation based on the characteristics of aged polypropylene microplastics (PP MPs). Our findings reveal that aging microplastics not only increased and expedited cancer cell proliferation but also induced tumorigenic behavior in immune cells. Furthermore, microplastics exposed to the environment for extended periods were found to contribute to cancer metastasis. We propose that microplastics with prolonged environmental exposure can have significant adverse effects on patients with cancer, affecting both cancer and immune cells.