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Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

Authors
최우진Sohyeon ParkJaeSung KwonEun-Young JangJIYOUNG KIMJiwoong HeoYoungDeok HwangBYEONG-SU KIMJi-Hoi MoonSungwon JungSUNG-HWAN CHOIHwankyu LeeHyo-Won AhnJINKEE HONG
Issue Date
Mar-2021
Publisher
AMER CHEMICAL SOC
Keywords
Zwitterionic polymer; in vivo antifouling; antipolyelectrolyte effect; implantable biomedical device; polymer science
Citation
ACS NANO, v.15, no.4, pp 6811 - 6828
Pages
18
Journal Title
ACS NANO
Volume
15
Number
4
Start Page
6811
End Page
6828
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/22962
DOI
10.1021/acsnano.0c10431
ISSN
1936-0851
Abstract
Zwitterionic polymers have extraordinary properties, that is, significant hydration and the so-called antipolyelectrolyte effect, which make them suitable for biomedical applications. The hydration induces an antifouling effect, and this has been investigated significantly. The antipolyelectrolyte effect refers to the extraordinary ion-responsive behavior of particular polymers that swell and hydrate considerably in physiological solutions. This actuation begins to attract attention to achieve in vivo antifouling that is challenging for general polyelectrolytes. In this study, we established the sophisticated cornerstone of the antipolyelectrolyte effect in detail, including (i) the essential parameters, (ii) experimental verifications, and (iii) effect of improving antifouling performance. First, we find that both osmotic force and charge screening are essential factors. Second, we identify the antipolyelectrolyte effect by visualizing the swelling and hydration dynamics. Finally, we verify that the antifouling performance can be enhanced by exploiting the antipolyelectrolyte effect and report reduction of 85% and 80% in ex and in vivo biofilm formation, respectively.
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