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Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions

Authors
HYO-JIN YOONYong Jae LeeSEWOOM BAEKYOUNG SHIN CHUNGDae-Hyun KimJae Hoon LeeYONGCHEOL SHINYOUNG MIN SHINChungsoon RyuHye-Seon KimSo Hyun AhnHeeyon KimYoung Bin WonINHA LEEMyung Jae JeonSiHyun ChoBYUNG SEOK LEEHak-Joon SungYoungsik Choi
Issue Date
Apr-2021
Publisher
American Association for the Advancement of Science
Keywords
ovarian spheroid
Citation
SCIENCE ADVANCES, v.7, no.18, pp.eabe8873
Journal Title
SCIENCE ADVANCES
Volume
7
Number
18
Start Page
eabe8873
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5255
DOI
10.1126/sciadv.abe8873
ISSN
2375-2548
Abstract
The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy
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College of Medicine > 의과대학 산부인과학교실 > 1. Journal Articles
College of Medicine > 의과대학 의학공학교실 > 1. Journal Articles

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