Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions
- Authors
- HYO-JIN YOON; Yong Jae Lee; SEWOOM BAEK; YOUNG SHIN CHUNG; Dae-Hyun Kim; Jae Hoon Lee; YONGCHEOL SHIN; YOUNG MIN SHIN; Chungsoon Ryu; Hye-Seon Kim; So Hyun Ahn; Heeyon Kim; Young Bin Won; INHA LEE; Myung Jae Jeon; SiHyun Cho; BYUNG SEOK LEE; Hak-Joon Sung; Youngsik Choi
- Issue Date
- Apr-2021
- Publisher
- American Association for the Advancement of Science
- Keywords
- ovarian spheroid
- Citation
- SCIENCE ADVANCES, v.7, no.18, pp eabe8873
- Journal Title
- SCIENCE ADVANCES
- Volume
- 7
- Number
- 18
- Start Page
- eabe8873
- URI
- https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5255
- DOI
- 10.1126/sciadv.abe8873
- ISSN
- 2375-2548
- Abstract
- The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy
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Collections - College of Medicine > 의과대학 의학공학교실 > 1. Journal Articles
- College of Medicine > 의과대학 산부인과학교실 > 1. Journal Articles
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