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Photothermally Modulatable and Structurally Disintegratable Sub-8-nm Au1Ag9 Embedded Nanoblocks for Combination Cancer Therapy Produced by Plug-in Assembly

Authors
Sungjae ParkKishwor PoudelJungho HwangSae Kwang KuChul Soon YongJong Oh KimJeong Hoon Byeon
Issue Date
Sep-2020
Publisher
AMER CHEMICAL SOC
Keywords
continuous-flow manufacturing; plug-in reactionwares; composite nanoblocks; photothermally modulatable; structurally disintegratable
Citation
ACS NANO, v.14, no.9, pp.11,040 - 11,054
Journal Title
ACS NANO
Volume
14
Number
9
Start Page
11,040
End Page
11,054
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5261
DOI
10.1021/acsnano.9b09731
ISSN
1936-0851
Abstract
As well as the exploration of translatable delivery nanosystems for cancer therapeutic agents, the development of automatable continuous-flow manufacturing technology comprising digitally controlled reactions for the on-demand production of pharmaceuticals is an important challenge in anticancer nanomedicine. Most attempts to resolve these issues have involved the development of alternative reactions, formulations, or constructs containing stimulus components aimed at producing multiple approaches for highly efficacious combination cancer therapies. However, there has been no report of a platform based on plug-in execution that enables continuous-flow manufacture in a compact, reconfigurable manner, although an optimal platform technology may be a prerequisite for the timely translation of recently developed nanomedicines. To this end, we describe the development of a platform toward digitizable, continuous manufacture by a serial combination of plug-in reactionwares (heating plates, a spraying cup, and a photochamber) for single-pass flow fabrication. Specifically, we fabricated three different composite nanoblocks consisting of Au1Ag9 (<8 nm; stimulus component), docetaxel (an anticancer drug), and bovine serum albumin (a protective and targeting agent) using our system, with the result of producing nanoblocks with photothermally modulatable and structurally disintegratable properties. These were examined for effectiveness in near-infrared-induced chemothermal cancer therapy and renal excretion of Au1Ag9 particles and exhibited high anticancer efficacy and warrantable biosafety.
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