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Zinc imidazolate framework-8 as a promising nitric oxide carrier

Authors
JUNJIRA TANUMHYEJOONGJEONG최문현DAHEUICHOIKYUNGTAEPARKJong Bum LeeJINKEE HONG
Issue Date
Nov-2020
Publisher
ELSEVIER SCIENCE INC
Keywords
Zinc imidazolate framework 8; Nitric oxide; Gas storage; pH-sensitive; Controlled gas release
Citation
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.91, pp.355 - 361
Journal Title
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume
91
Start Page
355
End Page
361
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5302
DOI
10.1016/j.jiec.2020.08.021
ISSN
1226-086X
Abstract
Uncontrollable release and unexpected release limit the use of nitric oxide (NO). To overcome this problem, we introduce ZIF-8 as a pH-responsive NO carrier. The flexible framework of ZIF-8 under the high-pressure condition causes the physically NO adsorption inside the SOD cage. ZIF-8 maintain the excellent gas storage ability under the physiological environment. The results show good pH-responsive ability. The gas could not be released out until the particle is in an acid condition. At low pH conditions, half of the gas is released in 1% of the total release duration. Interestingly, the half-release (t(1/2)) increases to 10% when the phosphate species exist in the acid surrounding. The gradual release can occur under neutral conditions with the existence of phosphate (t(1/2) 33%). From these results, we expect this ZIF-8 loading NO nanoparticles is lead to the design of innovative gas therapeutic delivery platforms using the advantage of the flexible framework for loading and releasing the gas molecule. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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