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Cationic cellulose nanocrystals complexed with polymeric siRNA for efficient anticancer drug delivery

Authors
YOUNG MIN KIMYoonSeok LeeKIM TAEHYUNGKYUNGJIK YANGKEONWOOKNAMDEOKYEONG CHOEYoung Hoon Roh
Issue Date
Nov-2020
Publisher
ELSEVIER SCI LTD
Keywords
Cellulose nanocrystals; siRNA delivery; Rolling circle transcription; Hydrothermal desulfation; Nanocomplex
Citation
CARBOHYDRATE POLYMERS, v.247, pp.116684-1 - 116684-11
Journal Title
CARBOHYDRATE POLYMERS
Volume
247
Start Page
116684-1
End Page
116684-11
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5303
DOI
10.1016/j.carbpol.2020.116684
ISSN
0144-8617
Abstract
Surface-modified cellulose nanocrystals (CNCs) were developed for efficient delivery of polymeric siRNA in cancer cells. Cationic CNCs were synthesized using the sequential process of hydrothermal desulfation and chemical modification following which, polymeric siRNA obtained using from a two-step process of rolling circle transcription and Mg2+ chelation was complexed with the modified CNCs by electrostatic interaction. The complexation efficiency was optimized for high drug loading and release in the cytoplasmic environment. The resultant nanocomplex showed significantly enhanced enzymatic stability, gene knockdown efficacy, and apoptosis-induced in vitro therapeutic effect. Our results suggest CNCs as a promising carbohydrate-based delivery platform which could be utilized for RNAi-mediated cancer therapeutics.
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College of Life Science and Biotechnology > Biotechnology > 1. Journal Articles
일반대학원 > 일반대학원 생명과학부 > 1. Journal Articles

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