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Co-delivery of antigens and immunostimulants via a polymersome for improvement of antigen-specific immune response

Authors
JONGWOO LIMWoonsung NaHYUNOUK KIMMinjoo YeomAram KangGEUNSEON PARKChaewon ParkJISUN KISOJEONG LEEBud JungHyoung Hwa JeongDaewon ParkDaesub SongSEUNGJOO HAAM
Issue Date
Jul-2020
Publisher
ROYAL SOC CHEMISTRY
Keywords
Co-delivery; antigens
Citation
JOURNAL OF MATERIALS CHEMISTRY B, v.8, no.26, pp.5,620 - 5,626
Journal Title
JOURNAL OF MATERIALS CHEMISTRY B
Volume
8
Number
26
Start Page
5,620
End Page
5,626
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5313
DOI
10.1039/d0tb00892c
ISSN
2050-750X
Abstract
Cellular uptake of antigens (Ags) by antigen-presenting cells (APCs) is vital for effective functioning of the immune system. Intramuscular or subcutaneous administration of vaccine Ags alone is not sufficient to elicit optimal immune responses. Thus, adjuvants are required to induce strong immunogenicity. Here, we developed nanoparticulate adjuvants that assemble into a bilayer spherical polymersome (PSome) to promote the cellular uptake of Ags by APCs. PSomes were synthesized by using a biodegradable and biocompatible block copolymer methoxy-poly(ethylene glycol)-b-poly(D,L-lactide) to encapsulate both hydrophilic and lipophilic biomacromolecules, such as ovalbumin (OVA) as a model Ag and monophosphoryl lipid A (MPLA) as an immunostimulant. After co-encapsulation of OVA and MPLA, the PSome synthetic vehicle exhibited the sustained release of OVA in cell environments and allowed efficient delivery of cargos into APCs. The administration of PSomes loaded with OVA and MPLA induced the production of interleukin-6 and tumor necrosis factor-alpha cytokines by macrophage activation in vitro and elicited effective Ag-specific antibody responses in vivo. These findings indicate that the nano-sized PSome may serve as a potent adjuvant for vaccine delivery systems to modulate enhanced immune responses.
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