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Cellulose nanocrystals as support nanomaterials for dual droplet-based freeform 3D printing

Authors
Hyung Sun YoonKYUNGJIK YANGYOUNG MIN KIMKEONWOOKNAMYoung Hoon Roh
Issue Date
Nov-2021
Publisher
ELSEVIER SCI LTD
Keywords
Freeform 3D printing; Support materials; Cellulose nanocrystals; Alginate hydrogel; Controlled drug delivery
Citation
CARBOHYDRATE POLYMERS, v.272, pp.118469-1 - 118469-10
Journal Title
CARBOHYDRATE POLYMERS
Volume
272
Start Page
118469-1
End Page
118469-10
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6023
DOI
10.1016/j.carbpol.2021.118469
ISSN
0144-8617
Abstract
The selection of sacrificial support materials is important in the fabrication of complex freeform structures. In this study, a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks was developed using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials. CNCs-CaCl2 mixture compositions and alginate concentrations were varied to enhance printability with rheological properties of shape fidelity and structural stability. The mixtures supported the shape of alginate and allowed CaCl2 diffusion-based cross-linking during 3D printing. The hydrogels showed rheological and physicochemical properties similar to those of pure alginate hydrogel, as CNCs were removed during post-printing processing. BSA-loaded multi-layered spheres, freeform 3D-printed for oral protein drug delivery, protected BSA in the gastric environment and provided controlled and sustained release of BSA into the intestinal environment as layer width and alginate concentration increased. This method can facilitate freeform 3D printing of diverse pseudoplastic biomaterial inks for biomedical applications.
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College of Life Science and Biotechnology > Biotechnology > 1. Journal Articles
일반대학원 > 일반대학원 생명과학부 > 1. Journal Articles

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