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Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

Authors
HYO-JIN YOONSonghyun LeeTAEYOUNGKIMSeung-Eun YuHYESEON KIMYOUNG SHIN CHUNGSeyong ChungSUJI PARKYONGCHEOL SHINEUNKYUNG WANGJIHYE NOHHyun Jung KimCheol Ryong Kuhong KohCHANGSOO KIMJoon-Sang ParkYOUNG MIN SHINHak-Joon Sung
Issue Date
Dec-2022
Publisher
Ke Ai Publishing
Keywords
Nanomicelle; Injectable hydrogel; Peptide display; Theranostic; All-in-one treatment
Citation
Bioactive Materials, v.18, pp.433 - 445
Journal Title
Bioactive Materials
Volume
18
Start Page
433
End Page
445
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6292
DOI
10.1016/j.bioactmat.2022.03.031
ISSN
2452-199X
Abstract
All-in-one treatments represent a paradigm shift in future medicine. For example, inflammatory bowel disease (IBD) is mainly diagnosed by endoscopy, which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable hydrogels. Furthermore, molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free therapy. This study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable component. These properties enabled spraying of the hydrogel onto the intestinal walls during endoscopy. Next, peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions, specifically by nanomicelles. The peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD initiation. Hence, the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5 (TLR5) as the main target of flagellin binding and Notch-1. The peptide binding potently suppressed inflammatory signaling without drug loading, where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis factor-alpha. The results were produced using a human colorectal cell line, clinical IBD patient cells, gut-on-a-chip, a mouse IBD model, and pig experiments to validate the translational utility.
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College of Medicine > 의과대학 소아과학교실 > 1. Journal Articles
College of Medicine > 의과대학 의학공학교실 > 1. Journal Articles

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