Nature-derived, biocompatible silibinin based bioresorbable neuromorphic device for implantable medical electronics
- Authors
- Choi, Dong Hyun; Kim, Hyung Tae; Kim, Young; Park, Kyungho; Kim, Min Seong; Lee, Jin Hyeok; Kim, Gwan In; Chung, Justin J.; 김현재
- Issue Date
- Jun-2023
- Publisher
- ELSEVIER
- Citation
- APPLIED SURFACE SCIENCE, v.621
- Journal Title
- APPLIED SURFACE SCIENCE
- Volume
- 621
- URI
- https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6498
- DOI
- 10.1016/j.apsusc.2023.156814
- ISSN
- 0169-4332
1873-5584
- Abstract
- Implantable medical electronics require strict standards distinct that are from conventional electronics, such as high data throughput of various signals from a living body and anti-inflammatory responses after a surgical operation. In addition, there is a major concern that the implanted medical device should be removed through additional surgery when its lifespan expires, or duty is terminated. Here, a nature-derived biomaterial silibinin (SLB)-based neuromorphic device that satisfies the requirements of implantable medical electronics is presented. SLB is a biocompatible and bioresorbable material extracted from milk thistle seeds and is mainly used as a pharmaceutical drug for fatty liver disease or cancer. The SLB-based neuromorphic device shows synaptic be-haviors, such as a 130 % of paired-pulse facilitation index, potentiation-depression property, and short term-to -long term memory transition behavior of biological synapses. The synaptic behavior of the device is attributed to the MgOx formed by the redox reaction between the Mg electrode and the SLB layer with oxygen functional groups. Furthermore, SLB-based neuromorphic device fabricated on the biopolymer is fully biodegraded within 8 h. It is confirmed to have excellent biocompatibility by performing a cytotoxicity test for 120 h. These results suggest that SLB-based neuromorphic devices are a potential solution for implantable medical electronics.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Electrical and Electronic Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6498)
Items in Scholar Hub are protected by copyright, with all rights reserved, unless otherwise indicated.