Optimization of Layered Dissolving Microneedle for Sustained Drug Delivery Using Heat-Melted Poly(Lactic-Co-glycolic Acid)
- Authors
- Lee, Chisong; Kim, Jinkyung; Um, Daniel Junmin; Kim, Youseong; Min, Hye Su; Shin, Jiwoo; Nam, Jee Hye; Kang, Geonwoo; Jang, Mingyu; Yang, Huisuk; Jung, Hyungil
- Issue Date
- Jul-2021
- Publisher
- MDPI
- Keywords
- poly(lactic-co-glycolic acid); dissolving microneedle; sustained release; melting method; thermoplastic characteristics; drug delivery system
- Citation
- PHARMACEUTICS, v.13, no.7
- Journal Title
- PHARMACEUTICS
- Volume
- 13
- Number
- 7
- URI
- https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6585
- DOI
- 10.3390/pharmaceutics13071058
- ISSN
- 1999-4923
1999-4923
- Abstract
- Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose a novel heat-melting method for the fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without the use of potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted of a middle layer of the DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from the patch within 10 min, enhancing user compliance, and the encapsulated molecules were released for nearly 4 weeks thereafter. In conclusion, the geometry of HMP-DMNs was successfully optimized for safe and effective transdermal sustained drug delivery without the use of organic solvents. This study provides a strategy for the innovative utilization of PLGA as a material for transdermal drug delivery systems.
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Collections - 일반대학원 > 일반대학원 생명과학부 > 1. Journal Articles
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