Association between circadian preference and blood lipid levels using a 1:1:1 propensity score matching analysis
- Authors
- Kwon, Yu-Jin; Chung, Tae-Ha; Lee, Hye Sun; Park, JuYoung; Chung, Ji-Youn; Lee, Byoung-Kwon; Lee, Ji-Won
- Issue Date
- Aug-2019
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Circadian preference; Morningness-Eveningness Questionnaire; Lipid profile
- Citation
- JOURNAL OF CLINICAL LIPIDOLOGY, v.13, no.4, pp 645 - 653
- Pages
- 9
- Journal Title
- JOURNAL OF CLINICAL LIPIDOLOGY
- Volume
- 13
- Number
- 4
- Start Page
- 645
- End Page
- 653
- URI
- https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/6623
- DOI
- 10.1016/j.jacl.2019.04.007
- ISSN
- 1933-2874
1876-4789
- Abstract
- BACKGROUND: Previous studies indicate that circadian preference is associated with various energy metabolism and metabolic disorders. However, little is known about the associations between a circadian rhythm and blood lipid levels, especially in humans. OBJECTIVE: The aim of the study was to investigate whether the circadian rhythm affects serum lipid levels in Korean adults. METHODS: We designed a cross-sectional study to evaluate the associations between circadian preference and blood lipid levels in Korean adults. A total of 1984 participants (range of age 19-81 years) were included in this study. Propensity scores were calculated using logistic regression with age, sex, and body mass index. A total of 435 subjects were evaluated by propensity score matching analysis, equally distributed into morningness, intermediate, and eveningness groups, each with 145 subjects. Circadian preference was evaluated by the Morningness-Eveningness Questionnaire. RESULTS: Participants with the evening preference had significantly higher levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and non high-density lipoprotein cholesterol (non HDL-C) when compared with those with morning or intermediate preference, after adjusting for confounding variables. Regarding other lipid parameters, both total cholesterol/HDL-C and low density lipoprotein cholesterol/HDL-C in the evening preference are significantly higher than those of other circadian preferences. Evening preference was also significantly associated with a higher atherogenic index of plasma. CONCLUSION: Our study demonstrates that there is a significant association between circadian preference and blood lipid levels. Our findings suggest that individuals with evening preference could have a greater risk of atherosclerotic cardiovascular diseases. (C) 2019 National Lipid Association. All rights reserved.
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