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Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation

Authors
Soojeong ChoiJong Seung LeeJisoo ShinMin Suk LeeDonyoung KangNathaniel S. HwangHyungsuk LeeHee Seok YangSeung-Woo Cho
Issue Date
Nov-2020
Publisher
ELSEVIER SCIENCE BV
Keywords
Bone regeneration; Hyaluronic acid; Hydroxyapatite; Osteoconductive hydrogel patch; Pyrogallol; Whitlockite
Citation
JOURNAL OF CONTROLLED RELEASE, v.327, pp.571 - 583
Journal Title
JOURNAL OF CONTROLLED RELEASE
Volume
327
Start Page
571
End Page
583
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5260
DOI
10.1016/j.jconrel.2020.09.006
ISSN
0168-3659
Abstract
Bio-inspired adhesive hydrogels have been applied to cell and drug delivery systems to address various tissue defects and disorders. However, adhesive hydrogels functionalized with phenolic moieties often lack osteoconductive capacity and mechanical properties for bone regeneration. In this study, we utilized the versatile chemical interactions of phenolic moieties to overcome such limitations in bone tissue engineering efforts. Highly osteoconductive hybrid hydrogel patches were fabricated by incorporating inorganic minerals, hydroxyapatite (HAP), or whitlockite (WKT), into pyrogallol-conjugated hyaluronic acid (HA-PG). The hybrid HA-PG patches exhibited improved mechanical strength and reinforced structural/physical properties owing to additional intermolecular complexation between oxidized PG moieties and ions released from inorganic particles. The sustained release of bone morphogenetic protein-2 (BMP-2) from hybrid patches was prolonged by combination of the inherent nucleophilic affinity of oxidized PG and electrostatic interactions between inorganic particles and BMP-2. With increased osteoconductivity, hybrid patches with HAP or WKT enhanced the osteogenic differentiation of human stem cells while also promoting new bone formation in a critical-sized calvarial defect. Our study demonstrates a translational potential of phenolic adhesive hydrogels engineered with inorganic minerals for orthopedic applications.
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College of Engineering > Mechanical Engineering > 1. Journal Articles
일반대학원 > 일반대학원 생명과학부 > 1. Journal Articles

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