Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording

Authors
이연택신효근이동원최성아조일주JUNGMOK SEO
Issue Date
Aug-2021
Publisher
Wiley-vch Verlag GmbH &Co
Keywords
Non-immunogenic; Neural probe; Longevity; Slippery; insertion trauma minimization
Citation
Advanced Science, v.8, no.15, pp.2100231-1 - 2100231-14
Journal Title
Advanced Science
Volume
8
Number
15
Start Page
2100231-1
End Page
2100231-14
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5275
DOI
10.1002/advs.202100231
ISSN
2198-3844
Abstract
Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune-stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Engineering > Electrical and Electronic Engineering > 1. Journal Articles

qrcode

Items in Scholar Hub are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Yeontaek photo

Lee, Yeontaek
College of Engineering (Electrical and Electronic Engineering)
Read more

Altmetrics

Total Views & Downloads

BROWSE