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Multifunctional DNA Nanogels for Aptamer-Based Targeted Delivery and Stimuli-Triggered Release of Cancer Therapeutics

Authors
KYUNGSENE LEEKIM TAEHYUNGYOUNG MIN KIMKYUNGJIK YANG최인석Young Hoon Roh
Issue Date
Jan-2021
Publisher
WILEY-V C H VERLAG GMBH
Keywords
cancer therapeutics; DNA nanogels; drug delivery; gold nanoparticles; stimuli?triggered release
Citation
MACROMOLECULAR RAPID COMMUNICATIONS, v.42, no.2, pp.2000457-1 - 2000457-6
Journal Title
MACROMOLECULAR RAPID COMMUNICATIONS
Volume
42
Number
2
Start Page
2000457-1
End Page
2000457-6
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5287
DOI
10.1002/marc.202000457
ISSN
1022-1336
Abstract
Targeted, stimulus-responsive DNA nanogels hold considerable promise for cancer therapeutics. To expand their functionality including thermoresponsiveness, here, multifunctional DNA nanogels are developed for potential application toward cancer-targeted delivery and stimuli-responsive release of cancer therapeutics. Three types of functionalized DNA nanobuilding units are formed into DNA nanogels of ?200?nm via sequence-dependent self-assembly. The sequence-dependent assembly of nanobuilding units is precisely designed for controlled assembly and thermal disassembly at physiological temperatures. The supramolecular structure exhibits multifunctionalities including temperature-induced disassembly, aptamer-mediated cancer cell targeting, and light-triggered temperature increase. The nanogels support co-loading of cancer therapeutics including anti-sense oligonucleotides and doxorubicin along with stimuli-responsive release of loaded drugs through temperature-responsive structural disassembly and pH-responsive deintercalation. The nanogels exhibit efficient aptamer-mediated cancer-specific intracellular delivery and combinational anticancer effects upon light triggering. The developed DNA nanogels, thus, constitute potential noncationic nanovectors for targeted delivery of combinational cancer therapeutics.
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College of Life Science and Biotechnology > Biotechnology > 1. Journal Articles
일반대학원 > 일반대학원 생명과학부 > 1. Journal Articles

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