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Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Authors
KIM TAEHYUNGHANA HYUNRoun HeoKEONWOOKNAMKYUNGJIK YANGYOUNG MIN KIMYoon Suk LeeJae Yoon AnJae Hyung ParkKi Young ChoiYoung Hoon Roh
Issue Date
Jun-2020
Publisher
ROYAL SOC CHEMISTRY
Keywords
RNA nanotechnology; rolling circle transcription; siRNA; dual-targeting; cancer therapy
Citation
CHEMICAL COMMUNICATIONS, v.56, no.49, pp.6,624 - 6,627
Journal Title
CHEMICAL COMMUNICATIONS
Volume
56
Number
49
Start Page
6,624
End Page
6,627
URI
https://yscholarhub.yonsei.ac.kr/handle/2021.sw.yonsei/5314
DOI
10.1039/d0cc01848a
ISSN
1359-7345
Abstract
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
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일반대학원 > 일반대학원 생명과학부 > 1. Journal Articles

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