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Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
- Authors
- KIM TAEHYUNG; HANA HYUN; Roun Heo; KEONWOOKNAM; KYUNGJIK YANG; YOUNG MIN KIM; Yoon Suk Lee; Jae Yoon An; Jae Hyung Park; Ki Young Choi; Young Hoon Roh
- Issue Date
- Jun-2020
- Publisher
- ROYAL SOC CHEMISTRY
- Keywords
- RNA nanotechnology; rolling circle transcription; siRNA; dual-targeting; cancer therapy
- Citation
- CHEMICAL COMMUNICATIONS, v.56, no.49, pp 6,624 - 6,627
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 56
- Number
- 49
- Start Page
- 6,624
- End Page
- 6,627
- ISSN
- 1359-7345
- Abstract
- A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.
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Related Researcher
- Kyungjik, Yang
- College of Life Science and Biotechnology (Biotechnology)